Study shows spike proteins affect cardiac pericytes and explain why soccer players collapse

An athlete’s muscles need a lot of oxygen when they’re playing, and the heart has to pump more blood to meet the oxygen demand,  and it has to beat faster. The rapid heart rate also increases the heart muscles’ oxygen need, and the heart’s blood vessels have to dilate to allow more blood to flow through.

If the heart’s oxygen demand is not met, the cardiac muscles cannot pump blood to the whole body, including the brain, and the brain stops functioning, and the player collapses.

If the player does not get immediate medical attention, the heart muscle dies, and so can the player. Heart attacks result from the lack of oxygen to the heart.

5 Soccer Players Die From Heart Attacks Believed To Be From Vaccine Side Effects

But why would it happen to a fit person? To answer that, let’s look at how blood vessels work.

Pericytes and Endothelial Cells

To ensure an adequate flow, the endothelial cells and pericytes in the cardiac blood vessels have to play as a team. The endothelial cells line the inside of the blood vessels and dilate them as needed.

Cardiac pericytes are smooth muscle cells lying outside the capillaries. They play vital roles in maintaining capillary integrity by working together with the endothelial cells that line the inside of the capillaries. [1]

Source: Mills et al. MDPI

A peer-reviewed research, The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signaling: a potential non-infective mechanism of COVID-19 microvascular disease may explain why some soccer players who got the COVID shots get heart damage.

The study was from the Bristol Medical School in the UK and published in Clinical Science. In brief, the paper showed that the spike protein of the SARS-CoV-2 can disrupt cardiac pericyte functions independent of a COVID19 infection. 

The research found that spike proteins by eliciting pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta, IL-1β, interleukin-6 IL-6, and monocyte chemoattractant protein-1 MCP1. The same cytokines are increased in patients with severe COVID-19 that have cytokine storms. The cytokines then cause damage to the heart muscles and form blood clots. 

The spike proteins also stimulate ERK1 and ERK2 and impair the “teamwork” of the pericytes and endothelial cells. The result is the death of endothelial cells. Once it dies, the cardiac blood vessels can not dilate to meet the demands of a rapidly beating heart.

The figure below is from the study and shows how the spike proteins affect the cardiac pericytes.

Source: Avolio et al. Clinical Science 2021

The study did not specifically mention that the COVID shots can disrupt the pericytes; however, their study shows that the harmful effect of the spike protein can happen without a COVID-19 infection—the same situation after COVID vaccinations.

The Role of COVID shots

After COVID vaccination, the messenger RNA is introduced to stimulate the body, then makes the spike proteins. These resulting spike proteins should stay firmly attached to the outside of the muscle cells where it was injected so that the immune system recognizes them and makes the specific immune response in the form of antibodies, T cells, and B cells.

In this Bristol study and another study by Kowarz et al. [4], some spike proteins become soluble and float in the bloodstream, ending up in other organs. One of which is the capillaries of the heart and produce inflammation and clot formation.

The heart of an athlete is strong and has an excellent blood supply, and that is why they can tolerate inflammation when at rest. However, once the heart has to beat fast, it must be 100% functional. If not, well, you will see something like this below.

Hypertension and COVID shots

There are other possible mechanisms for vascular damage after getting the shots like cell signaling, Kounis syndrome, and soluble proteins. All of which elicits inflammation and clot formation.  You can read about them at Higher blood pressure after COVID shots and why it happens

Don’t Get Sick!

by Jesse Santiano, M.D. Via