What Ingredients are in the COVID-19 Vaccine?

Pfzer-BioNTech Vaccine

• 95% efective

• Number of shots: 2 shots, 21 days apart

• Approved for use in people aged 16 years and older

• Ingredients: messenger ribonucleic acid (mRNA),
lipids (((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)
bis(2-hexyldecanoate), 2 [(polyethylene glycol)-2000]-
N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-
phosphocholine, and cholesterol), potassium chloride,
monobasic potassium phosphate, sodium chloride, dibasic
sodium phosphate dihydrate, and sucrose

• Explanation of ingredients:
– Lipids: Nanolipids, or tiny fat molecules, protect the mRNA
and provide a “greasy” exterior that helps the mRNA slide
inside cells. Nanolipid components in the Pfzer-BioNTech
vaccine include: ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-
diyl)bis(2-hexyldecanoate), 2 [(polyethylene glycol)-2000]-
N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-
phosphocholine, and cholesterol
– Salts: Helping to balance the acidity in your body, the following
salts are included in the Pfzer-BioNTech vaccine: potassium
chloride, monobasic potassium phosphate, sodium chloride,
and dibasic sodium phosphate dihydrate
– Sugar: Basic table sugar, also known as sucrose, can also be
found in the Pfzer-BioNTech vaccine. This ingredient helps the
molecules maintain their shape during freezing.

• Does NOT contain: Eggs, Preservatives, Latex

Learn more, read the FDA full Pfzer-BioNTech Fact Sheet:
http://www.fda.gov/media/144414/download

Moderna Vaccine

• 94% efective

• Number of shots: 2 shots, 28 days apart

• Approved for use in people aged 18 years and older

• Ingredients: messenger ribonucleic acid (mRNA),
lipids (SM-102, polyethylene glycol [PEG] 2000
dimyristoyl glycerol [DMG], cholesterol, and
1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]),
tromethamine, tromethamine hydrochloride,
acetic acid, sodium acetate, and sucrose

• Explanation of ingredients:
– mRNA: Like the Pfzer BioNTech vaccine, Moderna’s also uses
mRNA technology to build antibodies against COVID-19.
– Lipids: Nanolipids help deliver the mRNA to the vaccine
recipient’s cells. Nanolipid components of the Moderna
vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3-
methoxypolyethylene glycol-2000 [PEG2000-DMG], cholesterol,
and 1,2-distearoyl-snglycero-3-phosphocholine [DSPC])
– The remaining ingredients, including acids (acetic acid), acid
stabilizers (tromethamine and tromethamine hydrochloride),
salt (sodium acetate), and sugar (sucrose) all work together to
maintain the stability of the vaccine after it’s produced.

• Does NOT contain: Eggs, Preservatives, Latex

Learn more, read the FDA full Moderna Fact Sheet:
http://www.fda.gov/media/144638/download

How Does the COVID-19
Vaccine Work?

COVID-19 mRNA vaccines prepare our immune systems to protect us from COVID-19.

• COVID-19 mRNA vaccines provide instructions to cells in our upper arms to make a harmless protein found on the surface of the virus that causes COVID-19. Once this “spike protein” is made, the cell breaks down the instructions and gets rid of them.

• Our immune systems recognize that this spike protein doesn’t belong in our bodies and makes antibodies to bind onto the protein, signaling our immune cells to attack. This is called an immune response. mRNA vaccines provide instructions for our immune system to make antibodies without ever having to risk the serious consequences of getting sick with COVID-19 and passing
it on to others.

• It typically takes a couple weeks, but once an immune response to the spike protein is produced, our bodies canbrecognize the COVID-19 virus. Our immune system will automatically fght the virus to protect us from getting sick. Because it takes time to build this immune memory, it is possible to get COVID-19 just before or after vaccination when the vaccine is still working to provide protection.

Facts about COVID-19 mRNA Vaccines

They cannot give someone COVID-19.

mRNA vaccines do not use the live virus that causes COVID-19.

They do not affect or interact with our DNA in any way.

mRNA never enters the nucleus of the cell, which is where our DNA (genetic material) is kept. Cells break down and get rid of the mRNA soon after they are fnished using the instructions.

The two authorized vaccines require more than one shot.

You must receive 2 doses of the vaccine 3–4 weeks apart for maximum protection against COVID-19. The vaccine begins to protect you 1–2 weeks after your second dose.

Safety Data Sheet
acc. to OSHA HCS

1 Identification

· Product identifier

· Trade name: SM-102

· Synonym 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester

· Article number: 33474

· Application of the substance / the mixture For research use only, not for human or veterinary use.

· Details of the supplier of the safety data sheet

· Manufacturer/Supplier:
Cayman Chemical Co.
1180 E. Ellsworth Rd.
Ann Arbor, MI 48108
USA

· Information department: Product safety department
· Emergency telephone number:
During normal opening times: +1 (734) 971-3335
US/CANADA: 800-424-9300
Outside US/CANADA: 703-741-5970

2 Hazard(s) identification

· Classification of the substance or mixture

Symbol 3 icons by Vectors Market GHS02 Flame
Flam. Liq. 2 H225 Highly flammable liquid and vapor.

Hazard symbol - WikipediaGHS06 Skull and crossbones
Acute Tox. 2 H310 Fatal in contact with skin.

Know Your Hazard Symbols (Pictograms) | Office of Environmental Health and  SafetyGHS08 Health hazard
Carc. 2 H351 Suspected of causing cancer.
Repr. 2 H361 Suspected of damaging fertility or the unborn child.
STOT RE 1 H372 Causes damage to the central nervous system, the kidneys, the liver and the respiratory system through prolonged or repeated exposure.

File:GHS-pictogram-pollu.svg - Wikimedia CommonsGHS09 Environment
Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects.

Know Your Hazard Symbols (Pictograms) | Office of Environmental Health and  SafetyGHS07

Acute Tox. 4 H302 Harmful if swallowed.
Skin Irrit. 2 H315 Causes skin irritation.
Eye Irrit. 2A H319 Causes serious eye irritation.
Aquatic Acute 3 H402 Harmful to aquatic life.

· Label elements
· GHS label elements
The product is classified and labeled according to the Globally Harmonized System (GHS).
· Hazard pictograms

GHS02-GHS06-GHS07-GHS08-GHS09

· Signal word Danger
· Hazard-determining components of labeling:
Chloroform
· Hazard statements
H225 Highly flammable liquid and vapor.
H302 Harmful if swallowed.
H310 Fatal in contact with skin.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H351 Suspected of causing cancer.
H361 Suspected of damaging fertility or the unborn child.
H372 Causes damage to the central nervous system, the kidneys, the liver and the respiratory system through prolonged or repeated exposure.
H402 Harmful to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.

· Precautionary statements
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
Keep container tightly closed.
Ground/bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting/equipment.
Use only non-sparking tools.
Take precautionary measures against static discharge.
Do not breathe dust/fume/gas/mist/vapors/spray.
Do not get in eyes, on skin, or on clothing.
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
Avoid release to the environment.
Wear protective gloves/protective clothing/eye protection/face protection.
If swallowed: Call a poison center/doctor if you feel unwell.
If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy
to do. Continue rinsing.
Immediately call a poison center/doctor.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see on this label).
Get medical advice/attention if you feel unwell

Rinse mouth.
Take off immediately all contaminated clothing and wash it before reuse.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
In case of fire: Use for extinction: CO2, powder or water spray.
Collect spillage.
Store in a well-ventilated place. Keep cool.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
· Classification system:

· NFPA ratings (scale 0 – 4)

Health = 3
Fire = 3
Reactivity = 0

· HMIS-ratings (scale 0 – 4)

Health = 3
Fire = 3
Reactivity = 0

Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable

3 Composition/information on ingredients

· Chemical characterization: Mixtures
· Description: Mixture of the substances listed below with nonhazardous additions.

· Dangerous components:
CAS: 67-66-3
RTECS: FS9100000
Chloroform 90.0%
· Other ingredients
2089251-47-6 SM-102 10.0%

4 First-aid measures

· Description of first aid measures
· General information:
Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least
48 hours after the accident.
· After inhalation: In case of unconsciousness place patient stably in side position for transportation.
· After skin contact: Immediately wash with water and soap and rinse thoroughly.
· After eye contact:
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
· After swallowing: Immediately call a doctor.

· Information for doctor:
· Most important symptoms and effects, both acute and delayed
May cause anemia, cough, CNS depression, drowsiness, headache, heart damage, lassitude
(weakness, exhaustion), liver damage, narcosis, reproductive effects, teratogenic effects.
No further relevant information available.
· Indication of any immediate medical attention and special treatment needed
No further relevant information available.

5 Fire-fighting measures

· Extinguishing media
· Suitable extinguishing agents:
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
· For safety reasons unsuitable extinguishing agents: Water with full jet
· Special hazards arising from the substance or mixture
67-56-1During heating or in case of fire poisonous gases are produced.
· Advice for firefighters
· Protective equipment: Mouth respiratory protective device.

6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures
Mount respiratory protective device.
Wear protective equipment. Keep unprotected persons away.
· Environmental precautions:
Do not allow product to reach sewage system or any water course.
Inform respective authorities in case of seepage into water course or sewage system.
Do not allow to enter sewers/ surface or ground water.
· Methods and material for containment and cleaning up:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
· Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
· Protective Action Criteria for Chemicals

· PAC-1:
67-66-3 Chloroform 2 ppm

· PAC-2:
67-66-3 Chloroform 64 ppm

· PAC-3:
67-66-3 Chloroform 3,200 ppm

7 Handling and storage

· Handling:
· Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.

Prevent formation of aerosols.
· Information about protection against explosions and fires:
Keep ignition sources away – Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.
· Conditions for safe storage, including any incompatibilities
· Storage:
· Requirements to be met by storerooms and receptacles: Store in a cool location.
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions:
Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed receptacles.
· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical systems: No further data; see item 7.
· Control parameters
· Components with limit values that require monitoring at the workplace:
67-66-3 Chloroform
PEL Ceiling limit value: 240 mg/m³, 50 ppm
REL Short-term value: 9.78* mg/m³, 2* ppm
*60-min; See Pocket Guide App. A
TLV Long-term value: 49 mg/m³, 10 ppm

· Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls
· Personal protective equipment:
· General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
· Breathing equipment:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer
exposure use respiratory protective device that is independent of circulating air.
· Protection of hands:

Safety symbols Acc. to ISO 7010, Wear protective gloves, 200 mm | Safety  symbols | Marking | Occupational Safety and Personal Protection | Labware |  Carl Roth - InternationalProtective gloves

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation.

· Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.

· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has
to be observed.
· Eye protection:

Eye Symbol 600*600 transprent Png Free Download - Smile, Eyewear, Line. -  CleanPNG / KissPNGTightly sealed goggles 

9 Physical and chemical properties

· Information on basic physical and chemical properties
· General Information
· Appearance:

Form: Liquid
Color: According to product specification
· Odor: Characteristic
· Structural Formula C44H87NO5
· Molecular Weight 710.2
· Odor threshold: Not determined.
· Formulation A solution in chloroform
· pH-value: Not determined.
· Change in condition
Melting point/Melting range: Undetermined.
Boiling point/Boiling range: 62 °C (143.6 °F)
· Flash point: 0 °C (32 °F)
· Flammability (solid, gaseous): Not applicable.
· Ignition temperature: 982 °C (1,799.6 °F)
· Decomposition temperature: Not determined.
· Auto igniting: Product is not selfigniting.
· Danger of explosion: Product is not explosive. However, formation of explosive air/
vapor mixtures are possible.
· Explosion limits:
Lower: Not determined.
Upper: Not determined.
· Vapor pressure at 20 °C (68 °F): 210 hPa (157.5 mm Hg)
· Density at 20 °C (68 °F): 1.47988 g/cm³ (12.3496 lbs/gal)
· Bulk density: 1,480 kg/m³
· Relative density Not determined.
· Vapor density Not determined.
· Evaporation rate Not determined.
· Solubility in / Miscibility with
Water: Not miscible or difficult to mix.
· Partition coefficient (n-octanol/water): Not determined.

· Viscosity:
Dynamic at 20 °C (68 °F): 0.56 mPas
Kinematic: Not determined.
· Solvent content:
VOC content: 0.00 %
0.0 g/l / 0.00 lb/gal
Solids content: 1.0 %
· Other information No further relevant information available

10 Stability and reactivity

· Reactivity No further relevant information available.
· Chemical stability
· Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.
· Possibility of hazardous reactions No dangerous reactions known.
· Conditions to avoid No further relevant information available.
· Incompatible materials: No further relevant information available.
· Hazardous decomposition products: No dangerous decomposition products known

11 Toxicological information

· Information on toxicological effects
· Acute toxicity:
· LD/LC50 values that are relevant for classification:
ATE (Acute Toxicity Estimate)

Oral LD50 40 mg/kg (mouse)
Dermal LD50 83.3 mg/kg (rat)
67-66-3 Chloroform
Oral LDLO 2,514 mg/kg (man)
LD50 300 mg/kg (rat)
Dermal LD50 >20 g/kg (rabbit)
LD50 75 mg/kg (rat)
Inhalative LC50 47,702 mg/m³/4h (rat)
TCLO 5,000 mg/m³/7m (hmn)
Irritation of skin Irritation 10 mg/24h (rabbit)
Irritation of eyes Irritation 20 mg/24h (rabbit)
Intraperitoneal LD50 623 mg/kg (mouse)

· Primary irritant effect:
· on the skin: Irritant to skin and mucous membranes.
· on the eye: Irritating effect.
· Sensitization: No sensitizing effects known.
· Additional toxicological information:
The product shows the following dangers according to internally approved calculation methods for
preparations:

Harmful
Irritant
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
67-66-3 Chloroform 2B
· NTP (National Toxicology Program)
67-66-3 Chloroform R
· OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.

12 Ecological information

· Toxicity
· Aquatic toxicity: No further relevant information available.
· Persistence and degradability No further relevant information available.
· Behavior in environmental systems:
· Bioaccumulative potential No further relevant information available.
· Mobility in soil No further relevant information available.
· Additional ecological information:
· General notes:
Water hazard class 3 (Self-assessment): extremely hazardous for water
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
· Other adverse effects No further relevant information available.

13 Disposal considerations

· Waste treatment methods
· Recommendation:
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings:
· Recommendation: Disposal must be made according to official regulations

14 Transport information

· UN-Number
· DOT, IMDG, IATA UN1992
· UN proper shipping name
· DOT Flammable liquids, toxic, n.o.s. (Chloroform)
· IMDG F L A M M A B L E L I Q U I D , T O X I C , N . O . S .
(CHLOROFORM)

· IATA Flammable liquid, toxic, n.o.s. (CHLOROFORM)

· Transport hazard class(es)
· DOT

Class 6 toxic sign - dangerous goods diamond Hazard Labelling Symbol - Class 3 - Flammable liquid - White - Maritime  Progress Ltd Maritime Progress Ltd

· Class:  3 Flammable liquids
· Label:  3, 6.1

· IMDG

Class 6 toxic sign - dangerous goods diamond Hazard Labelling Symbol - Class 3 - Flammable liquid - White - Maritime  Progress Ltd Maritime Progress Ltd

· Class: 3 Flammable liquids
· Label: 3/6.1

· IATA

Class 6 toxic sign - dangerous goods diamond Hazard Labelling Symbol - Class 3 - Flammable liquid - White - Maritime  Progress Ltd Maritime Progress Ltd

· Class: 3 Flammable liquids
· Label: 3 (6.1)

· Packing group
· DOT, IMDG, IATA II
· Environmental hazards: Not applicable.
· Special precautions for user Warning: Flammable liquids
· Hazard identification number (Kemler code): 336
· EMS Number: F-E,S-D
· Segregation groups Liquid halogenated hydrocarbons
· Stowage Category B
· Stowage Code SW2 Clear of living quarters.
· Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code Not applicable.
· Transport/Additional information:
· DOT
· Quantity limitations On passenger aircraft/rail: 1 L
On cargo aircraft only: 60 L
· IMDG
· Limited quantities (LQ) 1L
· Excepted quantities (EQ) Code: E2
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
· IATA
· Remarks: When sold in quantities of less than or equal to 1 mL,
or 1 g, with an Excepted Quantity Code of E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
· UN “Model Regulation”: UN 1992 FLAMMABLE LIQUID, TOXIC, N.O.S.
(CHLOROFORM), 3 (6.1), II

15 Regulatory information

· Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
· Sara
· Section 355 (extremely hazardous substances):
67-66-3 Chloroform
· Section 313 (Specific toxic chemical listings):
67-66-3 Chloroform
· TSCA (Toxic Substances Control Act):
67-66-3 Chloroform ACTIVE
· Hazardous Air Pollutants
67-66-3 Chloroform
· Proposition 65
· Chemicals known to cause cancer:
67-66-3 Chloroform
· Chemicals known to cause reproductive toxicity for females:
None of the ingredients is listed.
· Chemicals known to cause reproductive toxicity for males:
None of the ingredients is listed.
· Chemicals known to cause developmental toxicity:
67-66-3 Chloroform
· Carcinogenic categories
· EPA (Environmental Protection Agency)
67-66-3 Chloroform B2, L, NL
· TLV (Threshold Limit Value)
67-66-3 Chloroform A3
· NIOSH-Ca (National Institute for Occupational Safety and Health)
67-66-3 Chloroform
· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other information

This information is based on our present knowledge. However, this shall not constitute a guarantee for
any specific product features and shall not establish a legally valid contractual relationship.
· Department issuing SDS: Environment protection department.
· Contact: –

· Date of preparation / last revision 04/11/2021 / –
· Abbreviations and acronyms:
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic
vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flam. Liq. 2: Flammable liquids – Category 2
Acute Tox. 4: Acute toxicity – Category 4
Acute Tox. 2: Acute toxicity – Category 2
Skin Irrit. 2: Skin corrosion/irritation – Category 2
Eye Irrit. 2A: Serious eye damage/eye irritation – Category 2A
Carc. 2: Carcinogenicity – Category 2
Repr. 2: Reproductive toxicity – Category 2
STOT RE 1: Specific target organ toxicity (repeated exposure) – Category 1
Aquatic Acute 3: Hazardous to the aquatic environment – acute aquatic hazard – Category 3
Aquatic Chronic 1: Hazardous to the aquatic environment – long-term aquatic hazard – Category 1

Via https://portal.ct.gov/Vaccine-Portal and https://www.caymanchem.com/