I think it will be worse than we can possibly imagine.
There is a concept of serial passage in virus research. You passage the virus through serial animal hosts until you select the attribute you want. You never give the virus time enough to evolve naturally and do what viruses want to do which is spread around and make friends. That is why all bacterial/viral/parasitic infections attenuate through time. The host and the bug achieve equilibrium with each other.
In these mRNA vaccines, we are vaccinating people against the very part of the virus that wants to mutate, ie the spike protein. We are inducing incredible immunologic pressure on the very part of the virus responsible for producing variants – we are giving it every reason to mutate.
That seems an…. unwise…strategy to me.
A human simply cannot produce enough neutralizing antibodies (remember that term) to clear 100% of an infection with any vaccine strategy. There were reports of variant already occurring before the first vaccine. Interesting that the variants are now increasing after the vaccination campaign, no?
So you remove 90% of virus A, attenuate an infection in a given individual, but are now harboring and giving sanctuary to variant B. There will be some cross immunity to B but studies have show than you need to have polyclonal antibodies, that is antibodies to multiple epitopes of the spike, to clear virus. We are not doing that with these mRNA vaccines.
We are essentially interfering with the natural evolution of a virus epidemic by promoting the mutation of the virus within a host while at the same time inducing passage within that host of virus that escaped the first immunological challenge.
So the vaccinated person may have attenuated covid infection, that is shown, but he/she is likely now now shedding variant virus that has a completely unknown profile of infectivity or lethality.
It will require very intensive molecular and immunologic studies to determine if these people are getting sick from variants they have no immunity for (either because their previous vaccination didn’t protect them or a new variant) versus an immune reaction known as ADE (antibody dependent enhancement) that is very well known in coronovirus infections.
Given the billions of dollars with zero liability these vaccine manufacturers have now – do you think that will happen?
The handling of the covid 19 will go down as the greatest public health disaster ever, imo.